Act 1: Stygian Badlands
Just Like the Old Days
Make a path through the wreckage by detonating explosive barrels and kicking scraps out of the way. You'll soon arrive at a Dropkit. These can be used to upgrade your weapons and check status on Skillshots. Simply Leash the kit to access the terminal. The first order of business is to gain 1,200 skillpoints to gain upgrades. Leash the enemies ahead to gain Voodoo Doll Skillshots worth about 100 points each.
The next area is filled with cacti and barrels to gain more points through Pricked and Enviro-Mental shots. Above will be a turret gunner, but they can be easily dealt with by leashing them down from their perch. As you move up the stairs you gain points by quick reacting to "critical events". Press the on screen button right away to maximize your bonus. When ready, head down through the gate and on to the next chapter.
Last Train from Explosion Town
Start by using the dropkit to replenish your ammo and buy upgrades as needed. Next slide down the water fall and kick the Skulls below. There will be a door ahead that Ishi will bust through, leading to the Skull's storage area. Complete the critical event reaction and then destroy the docked copters hanging above.
Leash and kill the enemies that arrive. Critical reaction again to spot a manned copter that can be rifled down for a Skyjack Skillshot. Leash the controls to the door and head outside. Destroy another copter and take the lift down. Kick in the barriers to Pancake the enemies and head up the ramp to a turret gunner. Leash this fool and pilfer his minigun. You'll want to use this on the pack of choppers that appears.
After the battle, move ahead to gain some Shocker kills and a crictical event with Ishi. You'll next face off with a minigun miniboss. You can use the dropkit to gain Peacemaker Carbine charges. The alternative is to simply run behind the area the boss emerged from and grab a minigun of your own. Use this new tool to kill the boss and any cronies that arrive.
Following the next cutscene, you'll be riding on a train. You'll have access to a minigun to help take down tanks and vultures and minigun bosses quickly. A giant wheel will appear in the distance and fire off spinning torpedoes. When the torpedoes come, shoot them down to keep from dying. Take the wheel off coarse by shooting the tanks on either side: First the right and then the left.
Whatever it is, it's Pissed
Run through the lower ridges and you'll spot a Vulture chopper in the distance. Take it down along with the other Skulls on foot, and enter the cave. There are tons of eggs that need to be shot up. However, this will waken some natural beast in the distance. Run like hell and give Ishi support to fix up the vulture, making your escape and ending the first Act.