You'll awaken in the Sprawl mental ward and will need to flee the Necromorph outbreak. You don't have the means to defense yourself, so dash quickly out of the room while the enemies are busy with other helpless patients.
Through the first gate you'll be startled by a lone Necromorph. Mash the on screen prompt to throw it off you. It will get smashed in the door and leave you to continue forward.
Keep an eye out for your first save point. These will come in handy as you may find yourself saving and reloading often during the course of the game. You'll spot two Sprawl Guards that will point their weapons at you, however they will soon be murdered by a passing Necromorph.
In the next room you'll encounter a less than sane doctor who will threaten you before offing himself. Take the time to five finger discount some healing items and restore your health. You can also now use your objective finder to locate paths to your goal.
Follow the path to the maintenance tunnel and climb through. You'll land in the medical room where you can acquire the kinesis module. Since you have no weapon at the moment, the module will all you to grab and throw items with kinetic force. Use any spare debris around the room, such as steel beams, to smash a path. A Necromorph will appear, but it can be killed by throwing another broken piece of ship at it.
You'll soon arrive at a path blocked by a strapped, flailing Necromorph. enter the surgery room just to the left and you'll find yet another helpless patient. Activate the console to gain the Plasma Cutter. However, a Necromorph will appear and slay your new friend. Use your cutter to kill this Necromorph and reap vengeance. Return to the hall and kill the previous Necromorph to clear a path to the next door.
Search the area for extra cash and healing items. You'll want to be stocked for the fight ahead. In the next area you'll meet with Nolan Stross, another mental patient like yourself. After a brisk chat, you'll become swarmed by slash Necromorphs. These can be very deadly at close range, so you'll want to circle up the ramps and avoid being attacked from both sides. There is also a stash of medicine in one of the broken down vending machines. If you find yourself low on ammo, remember that you can also wield kinesis to throw limbs at the enemies. After the Necromorphs are dealt with, grab the Power Nodes on the front desk and continue on.
You'll arrive at the first hacking machine. Locate the blue "safe" areas and activate them before the time bar reaches zero. Right after solving the puzzles you'll gain access to stasis and will be ambushed by a lone Necromorph. You must stasis it and kill it quickly, as one hit from it will spell instant death, even during a new game+. After the Necromorph is dead, recharge your stasis at the machine in front of you. Use the stasis to free the malfunctioning door and move to the next area.
Grab the Power Node in the morgue and face off against a new type of Necromorph: Pukers, that shoot acidic vomit. Afterwards you'll come to a hall with a break able window, a shutter and some enemies. Blast the window and the vacuum will suck the enemies into space. However, it will also start pulling you. Shoot the panel above to lower the shutter and save yourself. in the next room is a store where you can spend credits on replacing gear. You will also find the plans for the Engineering suit that provide you with more health, defense, and inventory space.
Take a walk through the zero oxygen area to wind up at your first boss encounter. There are boxes scattered around the room that can be used to restock your ammo. Aim at the creatures legs to cripple it. There are also a few stasis chargers around the room, so keep the enemy slowed down. After blasting the Necromorph's limbs, move in for a kill shot or toss something at it via kinesis.